Decision Support Systems Paper Accepted on ADDIS: a Decision Support System for Evidence-Based Medicine

Recently, ECBI member dr. Tommi Tervonen published an article on ADDIS, which is a decision support system for evidence-based medicine in the prestigious Decision Support Systems journal, ranked P in the ERIM Journals List.


Clinical trials are the main source of information for the efficacy and safety evaluation of medical treatments. Although they are of pivotal importance in evidence-based medicine, there is a lack of usable information systems providing data-analysis and decision support capabilities for aggregate clinical trial results. This is partly caused by unavailability (i) of trial data in a structured format suitable for re-analysis, and (ii) of a complete data model for aggregate level results.

In his article, which is co-authored by dr. Gert van Valkenhoef, Tijs Zwinkels, prof.dr. Bert de Brock, and prof.dr. Hans Hillege of the University of Groningen, Tervonen develops a unifying data model that enables the development of evidence-based decision support in the absence of a complete data model. The supported decision processes are described and it is shown how these are implemented in the open source ADDIS software. ADDIS enables semi-automated construction of meta-analyses, network meta-analyses and benefit-risk decision models, and provides visualization of all results.

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Aggregate Data Drug Information System